Investigation of Extracellular Vesicles From SARS-CoV-2 Infected Specimens: A Safety Perspective

Investigation of Extracellular Vesicles From SARS-CoV-2 Infected Specimens: A Safety Perspective

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The coronavirus disease 2019 (COVID-19) pandemic, caused by the SARS-CoV-2 virus, is wreaking havoc around the world.Considering that extracellular vesicles (EVs) released from SARS-CoV-2 infected cells might play a role in a viremic phase contributing to disease progression and that standard methods for EV isolation have been reported to co-isolate viral particles, we would like to recommend the use of heightened laboratory safety measures borstlist självhäftande during the isolation of EVs derived from click here SARS-CoV-2 infected tissue and blood from COVID-19 patients.Research needs to be conducted to better understand the role of EVs in SARS-CoV-2 infectivity, disease progression, and transmission.EV isolation procedures should include approaches for protection from SARS-CoV-2 contamination.We recommend the EV and virology scientific communities develop collaborative projects where relationships between endogenous EVs and potentially lethal enveloped viruses are addressed to better understand the risks and pathobiology involved.